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Nisin is a type of antimicrobial peptide that is produced by certain strains of lactic acid bacteria, including Lactococcus lactis. It was first discovered in 1928 and is widely used in the food industry as a natural preservative to prevent the growth of harmful bacteria.

Over the years, numerous studies have been conducted on the properties and applications of nisin. Research has shown that nisin has a broad spectrum of antimicrobial activity, making it effective against a wide range of microorganisms, including both gram-positive and gram-negative bacteria.

One of the unique properties of nisin is its ability to bind to and disrupt the cell membranes of bacteria, leading to cell death. This mechanism of action makes it a potent and effective antimicrobial agent.

Nisin has been used as a natural preservative in a variety of food products, including cheese, meat, and canned foods. It has also been used as a potential alternative to antibiotics in the treatment of various infections.

In addition to its antimicrobial properties, nisin has also been found to have other potential health benefits. Studies have suggested that nisin may have anti-inflammatory, anti-cancer, and immunomodulatory effects, although further research is needed to fully understand these potential benefits.

Despite its many potential applications, there are also some limitations to the use of nisin. For example, nisin may have a negative impact on the fermentation process in some foods, and its effectiveness may be reduced in the presence of certain food additives or processing techniques.

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